SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
SARS-CoV-2 variants with spike (S)-protein D614G mutations currently predominate globally. Here, Zhang et al. hypothesize that D614G variant may increase infectivity by increasing S protein abundance on the virion since pseudoviruses carrying S-G614 incorporate higher amounts of S protein and enter...
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| Format: | Article |
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Nature Publishing Group
2020-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19808-4 |
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doaj-5ab81391dfd1486295e3c90c83762edb2021-05-11T08:25:31ZengNature Publishing GroupNature Communications2041-17232020-11-011111910.1038/s41467-020-19808-4SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivityLizhou Zhang0Cody B. Jackson1Huihui Mou2Amrita Ojha3Haiyong Peng4Brian D. Quinlan5Erumbi S. Rangarajan6Andi Pan7Abigail Vanderheiden8Mehul S. Suthar9Wenhui Li10Tina Izard11Christoph Rader12Michael Farzan13Hyeryun Choe14Department of Immunology and Microbiology, The Scripps Research InstituteDepartment of Immunology and Microbiology, The Scripps Research InstituteDepartment of Immunology and Microbiology, The Scripps Research InstituteDepartment of Immunology and Microbiology, The Scripps Research InstituteDepartment of Immunology and Microbiology, The Scripps Research InstituteDepartment of Immunology and Microbiology, The Scripps Research InstituteDepartment of Integrative Structural and Computational Biology, The Scripps Research InstituteDepartment of Immunology and Microbiology, The Scripps Research InstituteDepartment of Pediatrics, Division of Infectious Disease, Emory University School of MedicineDepartment of Pediatrics, Division of Infectious Disease, Emory University School of MedicineNational Institute of Biological Sciences, Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua UniversityDepartment of Integrative Structural and Computational Biology, The Scripps Research InstituteDepartment of Immunology and Microbiology, The Scripps Research InstituteDepartment of Immunology and Microbiology, The Scripps Research InstituteDepartment of Immunology and Microbiology, The Scripps Research InstituteSARS-CoV-2 variants with spike (S)-protein D614G mutations currently predominate globally. Here, Zhang et al. hypothesize that D614G variant may increase infectivity by increasing S protein abundance on the virion since pseudoviruses carrying S-G614 incorporate higher amounts of S protein and enter cells more efficiently than those carrying S-D614.https://doi.org/10.1038/s41467-020-19808-4 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Lizhou Zhang Cody B. Jackson Huihui Mou Amrita Ojha Haiyong Peng Brian D. Quinlan Erumbi S. Rangarajan Andi Pan Abigail Vanderheiden Mehul S. Suthar Wenhui Li Tina Izard Christoph Rader Michael Farzan Hyeryun Choe |
| spellingShingle |
Lizhou Zhang Cody B. Jackson Huihui Mou Amrita Ojha Haiyong Peng Brian D. Quinlan Erumbi S. Rangarajan Andi Pan Abigail Vanderheiden Mehul S. Suthar Wenhui Li Tina Izard Christoph Rader Michael Farzan Hyeryun Choe SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity Nature Communications |
| author_facet |
Lizhou Zhang Cody B. Jackson Huihui Mou Amrita Ojha Haiyong Peng Brian D. Quinlan Erumbi S. Rangarajan Andi Pan Abigail Vanderheiden Mehul S. Suthar Wenhui Li Tina Izard Christoph Rader Michael Farzan Hyeryun Choe |
| author_sort |
Lizhou Zhang |
| title |
SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity |
| title_short |
SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity |
| title_full |
SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity |
| title_fullStr |
SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity |
| title_full_unstemmed |
SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity |
| title_sort |
sars-cov-2 spike-protein d614g mutation increases virion spike density and infectivity |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-11-01 |
| description |
SARS-CoV-2 variants with spike (S)-protein D614G mutations currently predominate globally. Here, Zhang et al. hypothesize that D614G variant may increase infectivity by increasing S protein abundance on the virion since pseudoviruses carrying S-G614 incorporate higher amounts of S protein and enter cells more efficiently than those carrying S-D614. |
| url |
https://doi.org/10.1038/s41467-020-19808-4 |
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