Role of Poly [ADP-ribose] Polymerase 1 in Activating the <i>Kirsten</i> <i>ras</i> (<i>KRAS</i>) Gene in Response to Oxidative Stress

Role of Poly [ADP-ribose] Polymerase 1 in Activating the <i>Kirsten</i> <i>ras</i> (<i>KRAS</i>) Gene in Response to Oxidative Stress

In pancreatic Panc-1 cancer cells, an increase of oxidative stress enhances the level of 7,8-dihydro-8-oxoguanine (8OG) more in the <i>KRAS</i> promoter region containing G4 motifs than in non-G4 motif G-rich genomic regions. We found that H<sub>2</sub>O<sub>2</sub&g...

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Bibliographic Details
Main Authors: Giorgio Cinque, Annalisa Ferino, Erik B. Pedersen, Luigi E. Xodo
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
G4 DNA
<i>KRAS</i>
oxidative stress
8-oxoguanine
PARP-1
transcription factors
Online Access:https://www.mdpi.com/1422-0067/21/17/6237

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https://www.mdpi.com/1422-0067/21/17/6237

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