Role of Poly [ADP-ribose] Polymerase 1 in Activating the <i>Kirsten</i> <i>ras</i> (<i>KRAS</i>) Gene in Response to Oxidative Stress
In pancreatic Panc-1 cancer cells, an increase of oxidative stress enhances the level of 7,8-dihydro-8-oxoguanine (8OG) more in the <i>KRAS</i> promoter region containing G4 motifs than in non-G4 motif G-rich genomic regions. We found that H<sub>2</sub>O<sub>2</sub&g...
Main Authors: | Giorgio Cinque, Annalisa Ferino, Erik B. Pedersen, Luigi E. Xodo |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-08-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/21/17/6237 |
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