Inhibition of fibroblast growth factor receptor 3-dependent lung adenocarcinoma with a human monoclonal antibody

Inhibition of fibroblast growth factor receptor 3-dependent lung adenocarcinoma with a human monoclonal antibody

Activating mutations in fibroblast growth factor receptor 3 (FGFR3) have been identified in multiple types of human cancer and in congenital birth defects. In human lung cancer, fibroblast growth factor 9 (FGF9), a high-affinity ligand for FGFR3, is overexpressed in 10% of primary resected non-small...

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Bibliographic Details
Main Authors: Yongjun Yin, Xiaodi Ren, Craig Smith, Qianxu Guo, Maria Malabunga, Ilhem Guernah, Yiwei Zhang, Juqun Shen, Haijun Sun, Nabil Chehab, Nick Loizos, Dale L. Ludwig, David M. Ornitz
Format: Article
Language:English
Published: The Company of Biologists 2016-05-01
Series:Disease Models & Mechanisms
Subjects:
Lung cancer
NSCLC
Fibroblast growth factor receptor 3
FGFR3
Adenocarcinoma
Inhibitory monoclonal antibody
Online Access:http://dmm.biologists.org/content/9/5/563

Internet

http://dmm.biologists.org/content/9/5/563

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