Contribution of intrinsic reactivity of the HIV-1 envelope glycoproteins to CD4-independent infection and global inhibitor sensitivity.

Contribution of intrinsic reactivity of the HIV-1 envelope glycoproteins to CD4-independent infection and global inhibitor sensitivity.

Human immunodeficiency virus (HIV-1) enters cells following sequential activation of the high-potential-energy viral envelope glycoprotein trimer by target cell CD4 and coreceptor. HIV-1 variants differ in their requirements for CD4; viruses that can infect coreceptor-expressing cells that lack CD4...

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Bibliographic Details
Main Authors: Hillel Haim, Bettina Strack, Aemro Kassa, Navid Madani, Liping Wang, Joel R Courter, Amy Princiotto, Kathleen McGee, Beatriz Pacheco, Michael S Seaman, Amos B Smith, Joseph Sodroski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-06-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3121797?pdf=render

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http://europepmc.org/articles/PMC3121797?pdf=render

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