An immunomodulating fatty acid analogue targeting mitochondria exerts anti-atherosclerotic effect beyond plasma cholesterol-lowering activity in apoe(-/-) mice.

An immunomodulating fatty acid analogue targeting mitochondria exerts anti-atherosclerotic effect beyond plasma cholesterol-lowering activity in apoe(-/-) mice.

Tetradecylthioacetic acid (TTA) is a hypolipidemic antioxidant with immunomodulating properties involving activation of peroxisome proliferator-activated receptors (PPARs) and proliferation of mitochondria. This study aimed to penetrate the effect of TTA on the development of atherosclerotic lesions...

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Bibliographic Details
Main Authors: Rita Vik, Marco Busnelli, Cinzia Parolini, Bodil Bjørndal, Sverre Holm, Pavol Bohov, Bente Halvorsen, Trond Brattelid, Stefano Manzini, Giulia S Ganzetti, Federica Dellera, Ottar K Nygård, Pål Aukrust, Cesare R Sirtori, Giulia Chiesa, Rolf K Berge
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3852987?pdf=render

Internet

http://europepmc.org/articles/PMC3852987?pdf=render

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