Role of the NMDA receptor in cognitive deficits, anxiety and depressive-like behavior in juvenile and adult mice after neonatal dexamethasone exposure

Role of the NMDA receptor in cognitive deficits, anxiety and depressive-like behavior in juvenile and adult mice after neonatal dexamethasone exposure

Postnatal dexamethasone (DEX) therapy has been used to treat or prevent chronic lung disease after premature births. However, there are many reports of long-term negative neurodevelopmental sequelae following this treatment. In contrast, hydrocortisone (HYD), which has fewer neurodevelopment adverse...

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Bibliographic Details
Main Authors: Su-Xia Li, Yuko Fujita, Ji-Chun Zhang, Qian Ren, Tamaki Ishima, Jin Wu, Kenji Hashimoto
Format: Article
Language:English
Published: Elsevier 2014-02-01
Series:Neurobiology of Disease
Subjects:
Dexamethasone
Hydrocortisone
NMDA receptor
GluN2B subunit
Cognition
Anxiety
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113002477

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http://www.sciencedirect.com/science/article/pii/S0969996113002477

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