Improved Lentiviral Gene Delivery to Mouse Liver by Hydrodynamic Vector Injection through Tail Vein

Improved Lentiviral Gene Delivery to Mouse Liver by Hydrodynamic Vector Injection through Tail Vein

Delivery of genes to mouse liver is routinely accomplished by tail-vein injections of viral vectors or naked plasmid DNA. While viral vectors are typically injected in a low-pressure and -volume fashion, uptake of naked plasmid DNA to hepatocytes is facilitated by high pressure and volumes, also kno...

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Bibliographic Details
Main Authors: Trine Dalsgaard, Claudia R. Cecchi, Anne Louise Askou, Rasmus O. Bak, Pernille O. Andersen, David Hougaard, Thomas G. Jensen, Frederik Dagnæs-Hansen, Jacob Giehm Mikkelsen, Thomas J. Corydon, Lars Aagaard
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Molecular Therapy: Nucleic Acids
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253118301458

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http://www.sciencedirect.com/science/article/pii/S2162253118301458

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