Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages

Sex hormone-binding globulin (SHBG) is a serum protein released mainly by the liver, and a low serum level correlates with a risk for metabolic syndrome including diabetes, obesity, and cardiovascular events. However, the underlying molecular mechanism(s) linking SHBG and metabolic syndrome remains...

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Main Authors: Hiroki Yamazaki, Akifumi Kushiyama, Hideyuki Sakoda, Midori Fujishiro, Takeshi Yamamotoya, Yusuke Nakatsu, Takako Kikuchi, Sunao Kaneko, Hirotoshi Tanaka, Tomoichiro Asano
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2018/3062319