Madecassoside Protects Against LPS-Induced Acute Lung Injury via Inhibiting TLR4/NF-κB Activation and Blood-Air Barrier Permeability

Madecassoside Protects Against LPS-Induced Acute Lung Injury via Inhibiting TLR4/NF-κB Activation and Blood-Air Barrier Permeability

Madecassoside (MA), a crucial ingredient of Centella asiatica, has been reported to exhibit a variety of bioactivities, including antipulmonary fibrosis, and antiinflammatory effects. Here we aimed to elucidate the protective effects and underlying mechanisms of MA on LPS-induced acute lung injury (...

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Bibliographic Details
Main Authors: Lu-Yuan Peng, Hai-Tao Shi, Meng Yuan, Jing-He Li, Ke Song, Jiang-Ni Huang, Peng-Fei Yi, Hai-Qing Shen, Ben-Dong Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Pharmacology
Subjects:
Madecassoside
acute lung injury
lipopolysaccharides
alveolar epithelium permeability
Toll-like receptor4/Nuclear factor kappa-B
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00807/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00807/full

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