Functional variants in NFKBIE and RTKN2 involved in activation of the NF-κB pathway are associated with rheumatoid arthritis in Japanese.

Functional variants in NFKBIE and RTKN2 involved in activation of the NF-κB pathway are associated with rheumatoid arthritis in Japanese.

Rheumatoid arthritis is an autoimmune disease with a complex etiology, leading to inflammation of synovial tissue and joint destruction. Through a genome-wide association study (GWAS) and two replication studies in the Japanese population (7,907 cases and 35,362 controls), we identified two gene loc...

Full description

Bibliographic Details
Main Authors: Keiko Myouzen, Yuta Kochi, Yukinori Okada, Chikashi Terao, Akari Suzuki, Katsunori Ikari, Tatsuhiko Tsunoda, Atsushi Takahashi, Michiaki Kubo, Atsuo Taniguchi, Fumihiko Matsuda, Koichiro Ohmura, Shigeki Momohara, Tsuneyo Mimori, Hisashi Yamanaka, Naoyuki Kamatani, Ryo Yamada, Yusuke Nakamura, Kazuhiko Yamamoto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3441678?pdf=render

Internet

http://europepmc.org/articles/PMC3441678?pdf=render

Similar Items