Correlation of the presence and extent of loss of heterozygosity mutations with histological classifications of Barrett’s esophagus

Correlation of the presence and extent of loss of heterozygosity mutations with histological classifications of Barrett’s esophagus

<p>Abstract</p> <p>Background</p> <p>Recent advances in the management of Barrett’s Esophagus (BE) have placed greater emphasis on accurate diagnosis of BE as well as better prediction of risk for progression to esophageal adenocarcinoma (EAC). Histological evaluation o...

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Bibliographic Details
Main Authors: Ellsworth Eric, Jackson Sara A, Thakkar Shyam J, Smith Dennis M, Finkelstein Sydney
Format: Article
Language:English
Published: BMC 2012-12-01
Series:BMC Gastroenterology
Subjects:
Barrett’s esophagus
Intestinal metaplasia
Indefinite for dysplasia
Low grade dysplasia
High grade dysplasia
Allelic imbalance
Loss of heterozygosity
Clonal expansion
Tumor suppressor gene mutation
Genomic instability
Online Access:http://www.biomedcentral.com/1471-230X/12/181

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http://www.biomedcentral.com/1471-230X/12/181

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