The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation

The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation

Background: Activation of the platelet-specific collagen receptor, glycoprotein (GP) VI, induces intracellular reactive oxygen species (ROS) production; however the relevance of ROS to GPVI-mediated platelet responses remains unclear. Objective: The objective of this study was to explore the role o...

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Bibliographic Details
Main Authors: T.G. Walsh, M.C. Berndt, N. Carrim, J. Cowman, D. Kenny, P. Metharom
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Redox Biology
Subjects:
Platelets
Glycoprotein VI
Reactive oxygen species
NAPDH oxidase
Thrombus
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231714000068

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http://www.sciencedirect.com/science/article/pii/S2213231714000068

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