The Interaction of Fluorinated Glycomimetics with DC-SIGN: Multiple Binding Modes Disentangled by the Combination of NMR Methods and MD Simulations

The Interaction of Fluorinated Glycomimetics with DC-SIGN: Multiple Binding Modes Disentangled by the Combination of NMR Methods and MD Simulations

Fluorinated glycomimetics are frequently employed to study and eventually modulate protein–glycan interactions. However, complex glycans and their glycomimetics may display multiple binding epitopes that enormously complicate the access to a complete picture of the protein–ligand complexes. We herei...

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Bibliographic Details
Main Authors: J. Daniel Martínez, Angela S. Infantino, Pablo Valverde, Tammo Diercks, Sandra Delgado, Niels-Christian Reichardt, Ana Ardá, Francisco Javier Cañada, Stefan Oscarson, Jesús Jiménez-Barbero
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Pharmaceuticals
Subjects:
NMR
molecular recognition
glycans
lectin
STD-NMR
DC-SIGN
Online Access:https://www.mdpi.com/1424-8247/13/8/179

Internet

https://www.mdpi.com/1424-8247/13/8/179

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