Drug Repositioning for Noonan and LEOPARD Syndromes by Integrating Transcriptomics With a Structure-Based Approach

Drug Repositioning for Noonan and LEOPARD Syndromes by Integrating Transcriptomics With a Structure-Based Approach

Noonan and LEOPARD syndromes (NS and LS) belong to a group of related disorders called RASopathies characterized by abnormalities of multiple organs and systems including hypertrophic cardiomyopathy and dysmorphic facial features. There are no approved drugs for these two rare diseases, but it is kn...

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Bibliographic Details
Main Authors: Liyuan Zhu, Ruth Roberts, Ruili Huang, Jinghua Zhao, Menghang Xia, Brian Delavan, Mike Mikailov, Weida Tong, Zhichao Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Pharmacology
Subjects:
transcriptomic profiles
molecular docking
induced pluripotent stem cell
drug repositioning
rare diseases
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00927/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00927/full

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