ErbB2-driven downregulation of the transcription factor Irf6 in breast epithelial cells is required for their 3D growth

ErbB2-driven downregulation of the transcription factor Irf6 in breast epithelial cells is required for their 3D growth

Abstract Background The ability of solid tumor cells to resist anoikis, apoptosis triggered by cell detachment from the extracellular matrix (ECM), is thought to be critical for 3D tumor growth. ErbB2/Her2 oncoprotein is often overproduced by breast tumor cells and blocks their anoikis by partially...

Full description

Bibliographic Details
Main Authors: Iman Aftab Khan, Byong Hoon Yoo, Michael McPhee, Olivier Masson, Alexi Surette, Kelly Dakin-Hache, Tallal Younis, Gillian Bethune, Kirill V. Rosen
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Breast Cancer Research
Subjects:
Anoikis
Apoptosis
ErbB2
Irf6
Breast cancer
Online Access:http://link.springer.com/article/10.1186/s13058-018-1080-1

Internet

http://link.springer.com/article/10.1186/s13058-018-1080-1

Similar Items