Inhibition of calcineurin by FK506 stimulates germinal vesicle breakdown of mouse oocytes in hypoxanthine-supplemented medium

Calcineurin (CN) is a serine/threonine phosphatase which plays important roles in meiosis maturation in invertebrate oocytes; however, the role of CN in mouse oocytes is relatively unexplored. In this study, we examined the expression, localization and functional roles of CN in mouse oocytes and gra...

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Bibliographic Details
Main Authors: Li Wang, Yan-Hong Zhen, Xiao-Ming Liu, Jing Cao, Yan-Ling Wang, Li-Jun Huo
Format: Article
Language:English
Published: PeerJ Inc. 2017-02-01
Series:PeerJ
Subjects:
MPF
Online Access:https://peerj.com/articles/3032.pdf