Structural Basis for Carbapenem-Hydrolyzing Mechanisms of Carbapenemases Conferring Antibiotic Resistance

Structural Basis for Carbapenem-Hydrolyzing Mechanisms of Carbapenemases Conferring Antibiotic Resistance

Carbapenems (imipenem, meropenem, biapenem, ertapenem, and doripenem) are β-lactam antimicrobial agents. Because carbapenems have the broadest spectra among all β-lactams and are primarily used to treat infections by multi-resistant Gram-negative bacteria, the emergence and spread of carbapenemases...

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Bibliographic Details
Main Authors: Jeong Ho Jeon, Jung Hun Lee, Jae Jin Lee, Kwang Seung Park, Asad Mustafa Karim, Chang-Ro Lee, Byeong Chul Jeong, Sang Hee Lee
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:International Journal of Molecular Sciences
Subjects:
carbapenemases
carbapenems
structure
catalytic mechanism
Online Access:http://www.mdpi.com/1422-0067/16/5/9654

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http://www.mdpi.com/1422-0067/16/5/9654

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