Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies

Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies

Activation of PDGFRA by genomic aberrations contributes to tumor progression in several tumor types. Here, the authors perform functional characterization of 16 novel PDGFRA mutations identified from different tumor types and demonstrate that a neomorphic PDGFRA extracellular domain driver mutation...

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Bibliographic Details
Main Authors: Carman K. M. Ip, Patrick K. S. Ng, Kang Jin Jeong, S. H. Shao, Zhenlin Ju, P. G. Leonard, Xu Hua, Christopher P. Vellano, Richard Woessner, Nidhi Sahni, Kenneth L. Scott, Gordon B. Mills
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06949-w

Internet

https://doi.org/10.1038/s41467-018-06949-w

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