Continuous Grading of Early Fibrosis in NAFLD Using Label-Free Imaging: A Proof-of-Concept Study.

BACKGROUND AND AIMS:Early detection of fibrosis is important in identifying individuals at risk for advanced liver disease in non-alcoholic fatty liver disease (NAFLD). We tested whether second-harmonic generation (SHG) and coherent anti-Stokes Raman scattering (CARS) microscopy, detecting fibrillar...

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Main Authors: Juho Pirhonen, Johanna Arola, Sanja Sädevirta, Panu Luukkonen, Sanna-Maria Karppinen, Taina Pihlajaniemi, Antti Isomäki, Mika Hukkanen, Hannele Yki-Järvinen, Elina Ikonen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4726624?pdf=render