HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex

HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex

Nuclear entry of HIV-1 replication complexes through intact nuclear pore complexes is critical for successful infection. The host protein cleavage-and-polyadenylation-specificity-factor-6 (CPSF6) has been implicated in different stages of early HIV-1 replication. Applying quantitative microscopy of...

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Bibliographic Details
Main Authors: David Alejandro Bejarano, Ke Peng, Vibor Laketa, Kathleen Börner, K Laurence Jost, Bojana Lucic, Bärbel Glass, Marina Lusic, Barbara Müller, Hans-Georg Kräusslich
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
Human immunodeficiency virus
CPSF6
macrophages
pre-integration complex
nuclear pore complex
nuclear import
Online Access:https://elifesciences.org/articles/41800

Internet

https://elifesciences.org/articles/41800

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