Forebrain Shh overexpression improves cognitive function and locomotor hyperactivity in an aneuploid mouse model of Down syndrome and its euploid littermates

Forebrain Shh overexpression improves cognitive function and locomotor hyperactivity in an aneuploid mouse model of Down syndrome and its euploid littermates

Abstract Down syndrome (DS) is the leading genetic cause of intellectual disability and causes early-onset dementia and cerebellar hypoplasia. The prevalence of attention deficit hyperactivity disorder is elevated in children with DS. The aneuploid DS mouse model “Ts65Dn” shows prominent brain pheno...

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Bibliographic Details
Main Authors: Feng J. Gao, Donna Klinedinst, Fabian-Xosé Fernandez, Bei Cheng, Alena Savonenko, Benjamin Devenney, Yicong Li, Dan Wu, Martin G. Pomper, Roger H. Reeves
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Acta Neuropathologica Communications
Subjects:
Down Syndrome
Sonic hedgehog
Cognitive function
Hyperactivity
Ts65Dn
TRE-hShh
Online Access:https://doi.org/10.1186/s40478-021-01237-z

Internet

https://doi.org/10.1186/s40478-021-01237-z

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