PPARγ activation improves the microenvironment of perivascular adipose tissue and attenuates aortic stiffening in obesity

PPARγ activation improves the microenvironment of perivascular adipose tissue and attenuates aortic stiffening in obesity

Abstract Background Obesity-related cardiovascular risk, end points, and mortality are strongly related to arterial stiffening. Current therapeutic approaches for arterial stiffening are not focused on direct targeting within the vessel. Perivascular adipose tissue (PVAT) surrounding the artery has...

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Bibliographic Details
Main Authors: Ju-Yi Chen, Yi-Pin Wu, Chih-Yi Li, Huei-Fen Jheng, Ling-Zhen Kao, Ching-Chun Yang, Sy-Ying Leu, I-Chia Lien, Wen-Tsan Weng, Haw-Chih Tai, Yu-Wei Chiou, Ming-Jer Tang, Pei-Jane Tsai, Yau-Sheng Tsai
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Journal of Biomedical Science
Subjects:
Arterial stiffness
Perivascular adipose tissue
Peroxisome proliferator-activated receptor γ
Obesity
Online Access:https://doi.org/10.1186/s12929-021-00720-y

Internet

https://doi.org/10.1186/s12929-021-00720-y

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