Discovery of Hybrid Dual N-Acylhydrazone and Diaryl Urea Derivatives as Potent Antitumor Agents: Design, Synthesis and Cytotoxicity Evaluation

Discovery of Hybrid Dual N-Acylhydrazone and Diaryl Urea Derivatives as Potent Antitumor Agents: Design, Synthesis and Cytotoxicity Evaluation

Based on the hybrid pharmacophore design concept, a novel series of dual diaryl urea and N-acylhydrazone derivatives were synthesized and evaluated for their in vitro cytotoxicity by the standard MTT assay. The pharmacological results indicated that most compounds exhibited moderate to excellent act...

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Bibliographic Details
Main Authors: Ping Gong, Hongyu Zhou, Di Wu, Nan Jiang, Qiang Huang, Xin Zhai
Format: Article
Language:English
Published: MDPI AG 2013-03-01
Series:Molecules
Subjects:
diaryl ureas
N-acylhydrazone
cytotoxicity
Online Access:http://www.mdpi.com/1420-3049/18/3/2904

Internet

http://www.mdpi.com/1420-3049/18/3/2904

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