dNTP Supply Gene Expression Patterns after P53 Loss

dNTP Supply Gene Expression Patterns after P53 Loss

Loss of the transcription factor p53 implies mRNA losses of target genes such as the p53R2 subunit of human ribonucleotide reductase (RNR). We hypothesized that other genes in the dNTP supply system would compensate for such p53R2 losses and looked for this in our own data and in data of the Gene Ex...

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Bibliographic Details
Main Authors: Mark Jackson, Charles A. Kunos, Gina Ferris, Damian Junk, Ian Lent, Yogen Saunthararajah, Tomas Radivoyevitch, John Pink
Format: Article
Language:English
Published: MDPI AG 2012-11-01
Series:Cancers
Subjects:
p53
Li-Fraumeni
ribonucleotide reductase
p53R2
dNTP supply and demand
gene expression
thymidine kinase
deoxyguanosine kinase
deoxycytidine kinase
Online Access:http://www.mdpi.com/2072-6694/4/4/1212

Internet

http://www.mdpi.com/2072-6694/4/4/1212

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