Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels

Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels

We report herein the design, synthesis and biological evaluation of new antioxidant and neuroprotective multitarget directed ligands (MTDLs) able to block Ca<sup>2+</sup> channels. New dialkyl 2,6-dimethyl-4-(4-(prop-2-yn-1-yloxy)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate MTDLs <b&...

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Bibliographic Details
Main Authors: Irene Pachòn Angona, Solene Daniel, Helene Martin, Alexandre Bonet, Artur Wnorowski, Maciej Maj, Krzysztof Jóźwiak, Tiago Barros Silva, Bernard Refouvelet, Fernanda Borges, José Marco-Contelles, Lhassane Ismaili
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
alzheimer’s disease
ca<sup>2+</sup> channel antagonists
hantzsch reaction
multitarget directed ligands
neuroprotection
oxidative stress
Online Access:https://www.mdpi.com/1420-3049/25/6/1329

Internet

https://www.mdpi.com/1420-3049/25/6/1329

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