Miniaturization and Automation of a Human In Vitro Blood–Brain Barrier Model for the High-Throughput Screening of Compounds in the Early Stage of Drug Discovery

Miniaturization and Automation of a Human In Vitro Blood–Brain Barrier Model for the High-Throughput Screening of Compounds in the Early Stage of Drug Discovery

Central nervous system (CNS) diseases are one of the top causes of death worldwide. As there is a difficulty of drug penetration into the brain due to the blood–brain barrier (BBB), many CNS drugs treatments fail in clinical trials. Hence, there is a need to develop effective CNS drugs following str...

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Bibliographic Details
Main Authors: Elisa L. J. Moya, Elodie Vandenhaute, Eleonora Rizzi, Marie-Christine Boucau, Johan Hachani, Nathalie Maubon, Fabien Gosselet, Marie-Pierre Dehouck
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceutics
Subjects:
blood–brain barrier (BBB)
in vitro models
BBB permeability
screening assays
automated system
CNS drug screening
Online Access:https://www.mdpi.com/1999-4923/13/6/892

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https://www.mdpi.com/1999-4923/13/6/892

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