Gene Silencing in Skin After Deposition of Self-Delivery siRNA With a Motorized Microneedle Array Device

Gene Silencing in Skin After Deposition of Self-Delivery siRNA With a Motorized Microneedle Array Device

Despite the development of potent siRNAs that effectively target genes responsible for skin disorders, translation to the clinic has been hampered by inefficient delivery through the stratum corneum barrier and into the live cells of the epidermis. Although hypodermic needles can be used to transpor...

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Bibliographic Details
Main Authors: Robyn P Hickerson, Winston C Wey, David L Rimm, Tycho Speaker, Susie Suh, Manuel A Flores, Emilio Gonzalez-Gonzalez, Devin Leake, Christopher H Contag, Roger L Kaspar
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
gene inhibition
nucleic acid therapeutics
reporter genes
siRNA delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301871

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http://www.sciencedirect.com/science/article/pii/S2162253116301871

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