A simple method for co-segregation analysis to evaluate the pathogenicity of unclassified variants; <it>BRCA1 </it>and <it>BRCA2 </it>as an example

A simple method for co-segregation analysis to evaluate the pathogenicity of unclassified variants; <it>BRCA1 </it>and <it>BRCA2 </it>as an example

<p>Abstract</p> <p>Background</p> <p>Assessment of the clinical significance of unclassified variants (UVs) identified in <it>BRCA1 </it>and <it>BRCA2 </it>is very important for genetic counselling. The analysis of co-segregation of the variant w...

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Bibliographic Details
Main Authors: Gómez García Encarna, van Os Theo A, Hogervorst Frans B, Verhoef Senno, Gille Johan J, Dommering Charlotte J, van der Luijt Rob B, Ausems Margreet G, Ligtenberg Marjolijn, Hoogerbrugge Nicoline, van der Hout Annemarie H, Oosterwijk Jan C, van den Ouweland Ans, Oldenburg Rogier, Vreeswijk Maaike P, Mohammadi Leila, Blok Marinus J, Wijnen Juul T, Helmer Quinta, Devilee Peter, van Asperen Christi J, van Houwelingen Hans C
Format: Article
Language:English
Published: BMC 2009-06-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/9/211

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http://www.biomedcentral.com/1471-2407/9/211

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