Analysis of Single Circulating Tumor Cells in Renal Cell Carcinoma Reveals Phenotypic Heterogeneity and Genomic Alterations Related to Progression

Analysis of Single Circulating Tumor Cells in Renal Cell Carcinoma Reveals Phenotypic Heterogeneity and Genomic Alterations Related to Progression

Circulating tumor cells (CTCs) are promising biomarkers for prognosis, therapeutic response prediction, and treatment monitoring in cancer patients. Despite its epithelial origin, renal cell carcinoma (RCC) shows low expression of epithelial markers hindering CTC-enrichment approaches exploiting epi...

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Bibliographic Details
Main Authors: Vera Cappelletti, Elena Verzoni, Raffaele Ratta, Marta Vismara, Marco Silvestri, Rosanna Montone, Patrizia Miodini, Carolina Reduzzi, Melanie Claps, Pierangela Sepe, Maria Grazia Daidone, Giuseppe Procopio
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
renal cell cancer
circulating tumor cells
heterogeneity
cancer evolution
copy number alterations
single-cell analysis
Online Access:https://www.mdpi.com/1422-0067/21/4/1475

Internet

https://www.mdpi.com/1422-0067/21/4/1475

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