Experimental heart failure causes depression-like behavior together with differential regulation of inflammatory and structural genes in the brain

Experimental heart failure causes depression-like behavior together with differential regulation of inflammatory and structural genes in the brain

Background-Depression and anxiety are common and independent outcome predictors in patients with chronic heart failure (CHF). However, it is unclear whether CHF causes depression. Thus, we investigated whether mice develop anxiety- and depression-like behavior after induction of ischemic CHF by myoc...

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Bibliographic Details
Main Authors: Anna eFrey, Sandy ePopp, Antonia ePost, Simon eLanger, Marc eLehmann, Ulrich eHofmann, Anna eSirén, Leif eHommers, Angelika eSchmitt, Tatyana eStrekalova, Georg eErtl, Klaus Peter eLesch, Stefan eFrantz
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Anxiety
Depression
Mice
Myocardial Infarction
chronic heart failure
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00376/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00376/full

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