TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
Increased inflammation during ageing promotes osteoporosis by activating osteoclast function and inhibiting osteoblasts. Here, the authors show that TGFβ1 release from bone matrix during ageing induces degradation of TRAF3 in mesenchymal progenitor cells, leading to reduced osteoblast differentiatio...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-06-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10677-0 |