TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
Increased inflammation during ageing promotes osteoporosis by activating osteoclast function and inhibiting osteoblasts. Here, the authors show that TGFβ1 release from bone matrix during ageing induces degradation of TRAF3 in mesenchymal progenitor cells, leading to reduced osteoblast differentiatio...
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2019-06-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-10677-0 |
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doaj-5b2df4499d844e86910a28da5979f4522021-05-11T11:44:33ZengNature Publishing GroupNature Communications2041-17232019-06-0110111510.1038/s41467-019-10677-0TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosisJinbo Li0Akram Ayoub1Yan Xiu2Xiaoxiang Yin3James O. Sanders4Addisu Mesfin5Lianping Xing6Zhenqiang Yao7Brendan F. Boyce8Department of Pathology and Laboratory Medicine, University of Rochester Medical CenterDepartment of Pathology and Laboratory Medicine, University of Rochester Medical CenterDepartment of Pathology and Laboratory Medicine, University of Rochester Medical CenterDepartment of Pathology and Laboratory Medicine, University of Rochester Medical CenterDepartment of Orthopaedics and Rehabilitation Medicine, University of Rochester Medical CenterDepartment of Orthopaedics and Rehabilitation Medicine, University of Rochester Medical CenterDepartment of Pathology and Laboratory Medicine, University of Rochester Medical CenterDepartment of Pathology and Laboratory Medicine, University of Rochester Medical CenterDepartment of Pathology and Laboratory Medicine, University of Rochester Medical CenterIncreased inflammation during ageing promotes osteoporosis by activating osteoclast function and inhibiting osteoblasts. Here, the authors show that TGFβ1 release from bone matrix during ageing induces degradation of TRAF3 in mesenchymal progenitor cells, leading to reduced osteoblast differentiation and increased osteoclast formation, and suggesting that pharmacological stabilization of TRAF3 could ameliorate age-related osteoporosis.https://doi.org/10.1038/s41467-019-10677-0 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jinbo Li Akram Ayoub Yan Xiu Xiaoxiang Yin James O. Sanders Addisu Mesfin Lianping Xing Zhenqiang Yao Brendan F. Boyce |
spellingShingle |
Jinbo Li Akram Ayoub Yan Xiu Xiaoxiang Yin James O. Sanders Addisu Mesfin Lianping Xing Zhenqiang Yao Brendan F. Boyce TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis Nature Communications |
author_facet |
Jinbo Li Akram Ayoub Yan Xiu Xiaoxiang Yin James O. Sanders Addisu Mesfin Lianping Xing Zhenqiang Yao Brendan F. Boyce |
author_sort |
Jinbo Li |
title |
TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis |
title_short |
TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis |
title_full |
TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis |
title_fullStr |
TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis |
title_full_unstemmed |
TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis |
title_sort |
tgfβ-induced degradation of traf3 in mesenchymal progenitor cells causes age-related osteoporosis |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2019-06-01 |
description |
Increased inflammation during ageing promotes osteoporosis by activating osteoclast function and inhibiting osteoblasts. Here, the authors show that TGFβ1 release from bone matrix during ageing induces degradation of TRAF3 in mesenchymal progenitor cells, leading to reduced osteoblast differentiation and increased osteoclast formation, and suggesting that pharmacological stabilization of TRAF3 could ameliorate age-related osteoporosis. |
url |
https://doi.org/10.1038/s41467-019-10677-0 |
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