TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis

Increased inflammation during ageing promotes osteoporosis by activating osteoclast function and inhibiting osteoblasts. Here, the authors show that TGFβ1 release from bone matrix during ageing induces degradation of TRAF3 in mesenchymal progenitor cells, leading to reduced osteoblast differentiatio...

Full description

Bibliographic Details
Main Authors:	Jinbo Li, Akram Ayoub, Yan Xiu, Xiaoxiang Yin, James O. Sanders, Addisu Mesfin, Lianping Xing, Zhenqiang Yao, Brendan F. Boyce
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-10677-0

id	doaj-5b2df4499d844e86910a28da5979f452
record_format	Article
spelling	doaj-5b2df4499d844e86910a28da5979f4522021-05-11T11:44:33ZengNature Publishing GroupNature Communications2041-17232019-06-0110111510.1038/s41467-019-10677-0TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosisJinbo Li0Akram Ayoub1Yan Xiu2Xiaoxiang Yin3James O. Sanders4Addisu Mesfin5Lianping Xing6Zhenqiang Yao7Brendan F. Boyce8Department of Pathology and Laboratory Medicine, University of Rochester Medical CenterDepartment of Pathology and Laboratory Medicine, University of Rochester Medical CenterDepartment of Pathology and Laboratory Medicine, University of Rochester Medical CenterDepartment of Pathology and Laboratory Medicine, University of Rochester Medical CenterDepartment of Orthopaedics and Rehabilitation Medicine, University of Rochester Medical CenterDepartment of Orthopaedics and Rehabilitation Medicine, University of Rochester Medical CenterDepartment of Pathology and Laboratory Medicine, University of Rochester Medical CenterDepartment of Pathology and Laboratory Medicine, University of Rochester Medical CenterDepartment of Pathology and Laboratory Medicine, University of Rochester Medical CenterIncreased inflammation during ageing promotes osteoporosis by activating osteoclast function and inhibiting osteoblasts. Here, the authors show that TGFβ1 release from bone matrix during ageing induces degradation of TRAF3 in mesenchymal progenitor cells, leading to reduced osteoblast differentiation and increased osteoclast formation, and suggesting that pharmacological stabilization of TRAF3 could ameliorate age-related osteoporosis.https://doi.org/10.1038/s41467-019-10677-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jinbo Li Akram Ayoub Yan Xiu Xiaoxiang Yin James O. Sanders Addisu Mesfin Lianping Xing Zhenqiang Yao Brendan F. Boyce
spellingShingle	Jinbo Li Akram Ayoub Yan Xiu Xiaoxiang Yin James O. Sanders Addisu Mesfin Lianping Xing Zhenqiang Yao Brendan F. Boyce TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis Nature Communications
author_facet	Jinbo Li Akram Ayoub Yan Xiu Xiaoxiang Yin James O. Sanders Addisu Mesfin Lianping Xing Zhenqiang Yao Brendan F. Boyce
author_sort	Jinbo Li
title	TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
title_short	TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
title_full	TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
title_fullStr	TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
title_full_unstemmed	TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
title_sort	tgfβ-induced degradation of traf3 in mesenchymal progenitor cells causes age-related osteoporosis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-06-01
description	Increased inflammation during ageing promotes osteoporosis by activating osteoclast function and inhibiting osteoblasts. Here, the authors show that TGFβ1 release from bone matrix during ageing induces degradation of TRAF3 in mesenchymal progenitor cells, leading to reduced osteoblast differentiation and increased osteoclast formation, and suggesting that pharmacological stabilization of TRAF3 could ameliorate age-related osteoporosis.
url	https://doi.org/10.1038/s41467-019-10677-0
work_keys_str_mv	AT jinboli tgfbinduceddegradationoftraf3inmesenchymalprogenitorcellscausesagerelatedosteoporosis AT akramayoub tgfbinduceddegradationoftraf3inmesenchymalprogenitorcellscausesagerelatedosteoporosis AT yanxiu tgfbinduceddegradationoftraf3inmesenchymalprogenitorcellscausesagerelatedosteoporosis AT xiaoxiangyin tgfbinduceddegradationoftraf3inmesenchymalprogenitorcellscausesagerelatedosteoporosis AT jamesosanders tgfbinduceddegradationoftraf3inmesenchymalprogenitorcellscausesagerelatedosteoporosis AT addisumesfin tgfbinduceddegradationoftraf3inmesenchymalprogenitorcellscausesagerelatedosteoporosis AT lianpingxing tgfbinduceddegradationoftraf3inmesenchymalprogenitorcellscausesagerelatedosteoporosis AT zhenqiangyao tgfbinduceddegradationoftraf3inmesenchymalprogenitorcellscausesagerelatedosteoporosis AT brendanfboyce tgfbinduceddegradationoftraf3inmesenchymalprogenitorcellscausesagerelatedosteoporosis
_version_	1721446063186903040

TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis

Similar Items