β3 phosphorylation of platelet αIIbβ3 is crucial for stability of arterial thrombus and microparticle formation in vivo

β3 phosphorylation of platelet αIIbβ3 is crucial for stability of arterial thrombus and microparticle formation in vivo

Abstract Background It is well accepted that functional activity of platelet integrin αIIbβ3 is crucial for hemostasis and thrombosis. The β3 subunit of the complex undergoes tyrosine phosphorylation shown to be critical for outside-in integrin signaling and platelet clot retraction ex vivo. However...

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Bibliographic Details
Main Authors: Weiyi Feng, Manojkumar Valiyaveettil, Tejasvi Dudiki, Ganapati H. Mahabeleshwar, Patrick Andre, Eugene A. Podrez, Tatiana V. Byzova
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Thrombosis Journal
Subjects:
β3 integrin phosphorylation
Outside-in integrin signaling
Microparticles
Arterial thrombosis
Online Access:http://link.springer.com/article/10.1186/s12959-017-0145-1

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http://link.springer.com/article/10.1186/s12959-017-0145-1

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