Fatostatin reverses progesterone resistance by inhibiting the SREBP1-NF-κB pathway in endometrial carcinoma

Abstract Progesterone resistance can significantly restrict the efficacy of conservative treatment for patients with endometrial cancer who wish to preserve their fertility or those who suffer from advanced and recurrent cancer. SREBP1 is known to be involved in the occurrence and progression of end...

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Bibliographic Details
Main Authors: Xiaohong Ma, Tianyi Zhao, Hong Yan, Kui Guo, Zhiming Liu, Lina Wei, Wei Lu, Chunping Qiu, Jie Jiang
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03762-0