Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease

Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease

Inflammation has been associated with the two classic lesions in the Alzheimer's (AD) brain, amyloid deposits and neurofibrillary tangles. Recent data suggest that Triflusal, a compound with potent anti-inflammatory effects in the central nervous system in vivo, might delay the conversion from...

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Bibliographic Details
Main Authors: M. Coma, L. Serenó, B. Da Rocha-Souto, T.C. Scotton, J. España, M.B. Sánchez, M. Rodríguez, J. Agulló, C. Guardia-Laguarta, M. Garcia-Alloza, L.A. Borrelli, J. Clarimón, A. Lleó, B.J. Bacskai, C.A. Saura, B.T. Hyman, T. Gómez-Isla
Format: Article
Language:English
Published: Elsevier 2010-06-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Transgenic mice
Triflusal
Amyloid
Neuroinflammation
Cytokines
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110000355

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http://www.sciencedirect.com/science/article/pii/S0969996110000355

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