Arsenic Trioxide and (−)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling

Arsenic Trioxide and (−)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling

Glioblastoma is one of the deadliest malignancies and is virtually incurable. Accumulating evidence indicates that a small population of cells with a stem-like phenotype is the major culprit of tumor recurrence. Enhanced DNA repair capacity and expression of stemness marker genes are the main charac...

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Bibliographic Details
Main Authors: Benedikt Linder, Andrej Wehle, Stephanie Hehlgans, Florian Bonn, Ivan Dikic, Franz Rödel, Volker Seifert, Donat Kögel
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cancers
Subjects:
cancer stem cells
glioblastoma
Hedgehog
Notch
DNA damage
Online Access:http://www.mdpi.com/2072-6694/11/3/350

Internet

http://www.mdpi.com/2072-6694/11/3/350

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