Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease

Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease

Abstract Background Older aged adults and those with pre-existing conditions are at highest risk for severe COVID-19 associated outcomes. Methods Using a large dataset of genome-wide RNA-seq profiles derived from human dermal fibroblasts (GSE113957) we investigated whether age affects the expression...

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Bibliographic Details
Main Authors: Stephen W. Bickler, David M. Cauvi, Kathleen M. Fisch, James M. Prieto, Alicia G. Sykes, Hariharan Thangarajah, David A. Lazar, Romeo C. Ignacio, Dale R. Gerstmann, Allen F. Ryan, Philip E. Bickler, Antonio De Maio
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Medical Genomics
Subjects:
SARS-CoV-2
Pattern recognition receptors
Toll-like receptor 4
Aging
Skin fibroblasts
Online Access:https://doi.org/10.1186/s12920-021-00970-7

Internet

https://doi.org/10.1186/s12920-021-00970-7

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