Hypercholesterolemia affects cardiac function, infarct size and inflammation in APOE*3-Leiden mice following myocardial ischemia-reperfusion injury.

Hypercholesterolemia affects cardiac function, infarct size and inflammation in APOE*3-Leiden mice following myocardial ischemia-reperfusion injury.

<h4>Background</h4>Hypercholesterolemia is a major risk factor for ischemic heart disease including acute myocardial infarction. However, long-term effects of hypercholesterolemia in a rodent myocardial ischemia-reperfusion injury model are unknown. Therefore, the effects of diet-induced...

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Bibliographic Details
Main Authors: Niek J Pluijmert, Melina C den Haan, Vanessa L van Zuylen, Paul Steendijk, Hetty C de Boer, Anton J van Zonneveld, Willem E Fibbe, Martin J Schalij, Paul H A Quax, Douwe E Atsma
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0217582

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https://doi.org/10.1371/journal.pone.0217582

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