Autologous Stem Cell Transplantation Promotes Mechanical Stretch Induced Skin Regeneration: A Randomized Phase I/II Clinical Trial

Autologous Stem Cell Transplantation Promotes Mechanical Stretch Induced Skin Regeneration: A Randomized Phase I/II Clinical Trial

Background: Mechanical stretch, in term of skin expansion, can induce effective but limited in vivo skin regeneration for complex skin defect reconstruction. We propose a strategy to obtain regenerated skin by combining autologous stem cell transplantation with mechanical stretch. Methods: This rand...

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Main Authors: Shuang-Bai Zhou, M.D., Ph.D., Guo-You Zhang, M.D., Ph.D., Yun Xie, M.D., Tao Zan, M.D., Ph.D., Yao-Kai Gan, M.D., Ph.D., Caroline A. Yao, M.D., M.S., Cheng-An Chiang, M.D., Jing Wang, M.D., Ph.D., Kai Liu, M.D., Ph.D., Hua Li, M.D., Ph.D., Jia Zhou, M.D., Ph.D., Mei Yang, M.D., Ph.D., Bin Gu, M.D., Feng Xie, M.D., Ph.D., Lee Q. Pu, M.D., Ph.D., William P. Magee III M.D., D.D.S., Qing-Feng Li, M.D., Ph.D.
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:EBioMedicine
Subjects:
Skin regeneration
Mechanical stretch
Skin expansion
Autologous stem cell
Bone mononuclear cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416304534

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http://www.sciencedirect.com/science/article/pii/S2352396416304534

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