Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11α Receptor

Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11α Receptor

Interleukin (IL)-11 signaling is involved in various processes, including epithelial intestinal cell regeneration and embryo implantation. IL-11 signaling is initiated upon binding of IL-11 to IL-11R1 or IL-11R2, two IL-11α-receptor splice variants, and gp130. Here, we show that IL-11 signaling via...

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Bibliographic Details
Main Authors: Niloufar Monhasery, Jens Moll, Carly Cuman, Manuel Franke, Larissa Lamertz, Rebecca Nitz, Boris Görg, Dieter Häussinger, Juliane Lokau, Doreen M. Floss, Roland Piekorz, Eva Dimitriadis, Christoph Garbers, Jürgen Scheller
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Cell Reports
Subjects:
IL-11
IL-11R
gp130
IL-6
transcytosis
apical
basolateral
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716308166

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http://www.sciencedirect.com/science/article/pii/S2211124716308166

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