Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence.

Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence.

Here we report the unexpected finding that specific human ANK2 variants represent a new example of balanced human variants. The prevalence of certain ANK2 (encodes ankyrin-B) variants range from 2 percent of European individuals to 8 percent in individuals from West Africa. Ankyrin-B variants associ...

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Bibliographic Details
Main Authors: Peter J Mohler, Jane A Healy, Hui Xue, Annibale A Puca, Crystal F Kline, R Rand Allingham, Evangelia G Kranias, Howard A Rockman, Vann Bennett
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2013943?pdf=render

Internet

http://europepmc.org/articles/PMC2013943?pdf=render

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