Lactate Dehydrogenase B and Pyruvate Oxidation Pathway Associated With Carfilzomib-Related Cardiotoxicity in Multiple Myeloma Patients: Result of a Multi-Omics Integrative Analysis

Lactate Dehydrogenase B and Pyruvate Oxidation Pathway Associated With Carfilzomib-Related Cardiotoxicity in Multiple Myeloma Patients: Result of a Multi-Omics Integrative Analysis

Multiple myeloma (MM) is the second most frequent hematologic cancer in the United States. Carfilzomib (CFZ), an irreversible proteasome inhibitor being used to treat relapsed and refractory MM, has been associated with cardiotoxicity, including heart failure. We hypothesized that a multi-omics appr...

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Bibliographic Details
Main Authors: Marwa Tantawy, Lakshmi Manasa Chekka, Yimei Huang, Timothy J. Garrett, Sonal Singh, Chintan P. Shah, Robert F. Cornell, Rachid C. Baz, Michael G. Fradley, Nida Waheed, David L. DeRemer, Lihui Yuan, Taimour Langaee, Keith March, Carl J. Pepine, Jan S. Moreb, Yan Gong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
proteasome inhibitors
Cardio-oncology
carfilzomib
metabolomcis
proteomic
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.645122/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2021.645122/full

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