Caffeine protects against stress-induced murine depression through activation of PPARγC1α-mediated restoration of the kynurenine pathway in the skeletal muscle

Caffeine protects against stress-induced murine depression through activation of PPARγC1α-mediated restoration of the kynurenine pathway in the skeletal muscle

Abstract Exercise prevents depression through peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α)-mediated activation of a particular branch of the kynurenine pathway. From kynurenine (KYN), two independent metabolic pathways produce neurofunctionally different metabolites, main...

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Bibliographic Details
Main Authors: Chongye Fang, Shuhei Hayashi, Xiaocui Du, Xianbin Cai, Bin Deng, Hongmei Zheng, Satoshi Ishido, Hiroko Tsutsui, Jun Sheng
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-86659-4

Internet

https://doi.org/10.1038/s41598-021-86659-4

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