Mitochondrial superoxide contributes to oxidative stress exacerbated by DNA damage response in RAD51-depleted ovarian cancer cells

Mitochondrial superoxide contributes to oxidative stress exacerbated by DNA damage response in RAD51-depleted ovarian cancer cells

Ovarian cancer is the most lethal gynecological malignancy. Abnormal homologous recombination repair, high level of reactive oxygen species (ROS) and upregulation of antioxidant genes are characteristic features of ovarian cancer. However, the molecular mechanisms governing the redox homeostasis in...

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Bibliographic Details
Main Authors: Limei Xu, Tingting Wu, Shihua Lu, Xiaohe Hao, Junchao Qin, Jing Wang, Xiyu Zhang, Qiao Liu, Beihua Kong, Yaoqin Gong, Zhaojian Liu, Changshun Shao
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Redox Biology
Subjects:
RAD51
Redox homeostasis
G2/M arrest
CHK1
Mitochondria stress
Ovarian cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720308090

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http://www.sciencedirect.com/science/article/pii/S2213231720308090

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