Homocysteine activates T cells by enhancing endoplasmic reticulum-mitochondria coupling and increasing mitochondrial respiration

Homocysteine activates T cells by enhancing endoplasmic reticulum-mitochondria coupling and increasing mitochondrial respiration

ABSTRACT Hyperhomocysteinemia (HHcy) accelerates atherosclerosis by increasing proliferation and stimulating cytokine secretion in T cells. However, whether homocysteine (Hcy)-mediated T cell activation is associated with metabolic reprogramming is unclear. Here, our in vivo and in vitro studies sho...

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Bibliographic Details
Main Authors: Juan Feng, Silin Lü, Yanhong Ding, Ming Zheng, Xian Wang
Format: Article
Language:English
Published: SpringerOpen 2016-02-01
Series:Protein & Cell
Subjects:
homocysteine
T cell
mitochondria
endoplasmic reticulum stress
Online Access:http://link.springer.com/article/10.1007/s13238-016-0245-x

Internet

http://link.springer.com/article/10.1007/s13238-016-0245-x

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