EARLY gestational exposure to isoflurane causes persistent cell loss in the dentate gyrus of adult male rats

EARLY gestational exposure to isoflurane causes persistent cell loss in the dentate gyrus of adult male rats

Abstract Background Our previous research showed that 4 h of maternal anesthesia with isoflurane during early gestation in pregnant rats leads to a deficit in spatial memory of adult male offspring. Because spatial memory is predominantly a hippocampally-mediated task, we asked the question if early...

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Bibliographic Details
Main Authors: Arvind Palanisamy, Gregory Crosby, Deborah J. Culley
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Behavioral and Brain Functions
Subjects:
Anesthesia during pregnancy
Anesthetic neurotoxicity
Maternal anesthesia
Spatial working memory
Stereology
Hippocampus
Online Access:http://link.springer.com/article/10.1186/s12993-017-0132-5

Internet

http://link.springer.com/article/10.1186/s12993-017-0132-5

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