Melatonin protects against apoptosis-inducing factor (AIF)-dependent cell death during acetaminophen-induced acute liver failure.

Melatonin protects against apoptosis-inducing factor (AIF)-dependent cell death during acetaminophen-induced acute liver failure.

Acetaminophen (APAP) overdose is the most frequent cause of acute liver failure and is primarily caused by cytochrome P450 (CYP) 2E1-driven conversion of APAP into hepatotoxic metabolites. Several reports showed that melatonin attenuated APAP-induced acute liver failure. Nevertheless, the exact mech...

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Bibliographic Details
Main Authors: Ying-Li Liang, Zhi-Hui Zhang, Xiao-Jing Liu, Xiao-Qian Liu, Li Tao, Ye-Fa Zhang, Hua Wang, Cheng Zhang, Xi Chen, De-Xiang Xu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3525654?pdf=render

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http://europepmc.org/articles/PMC3525654?pdf=render

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