Invariant NKT cells drive hepatic cytokinic microenvironment favoring efficient granuloma formation and early control of Leishmania donovani infection.

Invariant NKT cells drive hepatic cytokinic microenvironment favoring efficient granuloma formation and early control of Leishmania donovani infection.

The development of inflammatory granulomas around infected Kupffer cells is necessary for hepatic parasite clearance during visceral leishmaniasis. Invariant NKT (iNKT) cells are predominant T cells in the mouse liver and can synthesize large quantities of IL-4 and IFN-γ, two cytokines involved in g...

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Bibliographic Details
Main Authors: Florence Robert-Gangneux, Anne-Sophie Drogoul, Octavie Rostan, Claire Piquet-Pellorce, Jérome Cayon, Mariette Lisbonne, André Herbelin, Hugues Gascan, Claude Guiguen, Michel Samson, Jean-Pierre Gangneux
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3310876?pdf=render

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http://europepmc.org/articles/PMC3310876?pdf=render

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