4-Hydroxy-2-nonenal antimicrobial toxicity is neutralized by an intracellular pathogen
Pathogens encounter numerous antimicrobial responses during infection, including the reactive oxygen species (ROS) burst. ROS-mediated oxidation of host membrane poly-unsaturated fatty acids (PUFAs) generates the toxic alpha-beta carbonyl 4-hydroxy-2-nonenal (4-HNE). Although studied extensively in...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-05-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/59295 |